About 17 results found for searched term "TA 02" (0.262 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1813 | PCI-24781 | HDAC |
| Abexinostat; CRA-024781 | ||
| PCI-24781 is a novel and potent histone deacetylase (HDAC) inhibitor with IC50 value of 0.43 to 2.7 μM. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M1973 | Ostarine (GTx-024) | Androgen Receptor |
| MK-2866, GTx-024 | ||
| Ostarine (GTx-024 and MK-2866) is an investigational selective androgen receptor modulator (SARM) with Ki of 3.8 nM. | ||
| M2432 | Bardoxolone Methyl | IκB/IKK |
| RTA 402, TP-155, NSC 713200,CDDO Methyl ester | ||
| Bardoxolone Methyl is an IKK inhibitor with potent pro-apoptotic and anti-inflammatory activities, as well as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway. | ||
| M5238 | Bardoxolone | IκB/IKK |
| RTA 402; CCDO | ||
| Bardoxolone is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor. | ||
| M5249 | LX-4211 | SGLT |
| Sotagliflozin; LP-802034 | ||
| LX-4211 is an orally active, first-in-class dual SGLT1/2 inhibitor with IC50s of 36 nM and 1.8 nM, respectively, and is used in studies related to type 1 diabetes and heart failure. | ||
| M6146 | TA 02 | p38 MAPK |
| TA-02; TA02 | ||
| TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM. | ||
| M9020 | TAS-102 | DNA/RNA Synthesis |
| Trifluridine/Tipiracil HCl; Trifluridine-tipiracil hydrochloride mixture | ||
| TAS-102 is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride. | ||
| M9647 | Orludodstat (BAY-2402234) | DHODH |
| BAY-2402234 is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor for the treatment of myeloid malignancies, with an IC50 of 1.2 nM. | ||
| M5748 | MSDC-0602 | PPAR |
| Azemiglitazone; MSDC0602 | ||
| Azemiglitazone (MSDC-0602) is a PPARγ -retained thiazolidindione (TZD) that interacts with mitochondrial pyruvate vector (MPC) and inhibits its activity. | ||
| M10279 | Ibiglustat | Glucosylceramide Synthase |
| Venglustat; SAR402671; GZ402671 | ||
| Ibiglustat (Venglustat) is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. | ||
| M10434 | Olutasidenib (FT-2102) | Isocitrate Dehydrogenase (IDH) |
| FT-2102 | ||
| Olutasidenib (FT-2102) is a highly potent and selective, orally active, brain penetrant mutant Isocitrate dehydrogenase 1 (IDH1) inhibitor, with IC50 values of 21.2 nM and 114 nM for IDH1- R132H and IDH1- R132C, respectively. | ||
| M13688 | Soblidotin | Microtubule |
| Auristatin PE; TZT-1027 | ||
| Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. | ||
| M14716 | Ibiglustat (L-Malic acid) | Glucosylceramide Synthase |
| Venglustat (L-Malic acid); SAR402671 (L-Malic acid); GZ402671 (L-Malic acid) | ||
| Ibiglustat (Venglustat) L-Malic acid is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. | ||
| M20689 | Sparsentan (RE-021) | Endothelin Receptor |
| PS-433540; RE-021; DARA-a; BMS-346567 | ||
| Sparsentan (PS-433540, RE-021, DARA) is a first-in-class, orally active, high-affinity dual antagonist of the endothelin type A receptor (ETA) and Angiotensin II type 1 (AT1) receptor, with Ki values of 9.3 and 0.8 nM, respectively. | ||
| M21189 | TAK-020 | BTK |
| TAK-020 is a highly selective oral covalent BTK inhibitor with a promising safety and tolerability profile for both hematologic malignancies and autoimmune diseases. | ||
| M25429 | Rezafungin acetate | Anti-infection |
| Biafungin acetate; CD101 acetate; SP-3025 acetate | ||
| Rezafungin acetate is a novel echinocandin-based antifungal agent with potent antifungal activity against Candida, Aspergillus and Pneumocystis. | ||
| M52399 | Tau Peptide (74-102) (Exon 3/Insert 2 Domain) | Tau Protein |
| Tau Peptide (74-102) (Exon 3/Insert 2 Domain) is aTau fragment. | ||
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